脊髓融合术修复脊髓损伤的策略与进展
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1.广西中医药大学;2.广西中医药大学附属瑞康医院

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Strategies and Advance on Spinal Cord Fusion for Spinal Cord Injury Repair
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1.Guangxi University of Chinese Medicine;2.Department of Orthopedics,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine

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    摘要:

    脊髓损伤(SCI)是一种高度致残的中枢神经系统损伤,属于世界性临床医学难题。脊髓的再生能力低、神经可塑性差,SCI后囊性空洞和胶质瘢痕阻断神经传导, SCI修复难度大,目前临床上尚无SCI的有效治疗方法。“脊髓融合术”是一项修复SCI的新技术,其主要通过融合剂、锋利的刀和电刺激加速神经融合及修复进程,促进神经轴突再生、重组完整的神经传导环路,最终达到修复SCI相应功能的目的。本文回顾了历年SCI相关研究,对“脊髓融合术”的内涵、重要研究进展及神经学机制进行综述并探讨,旨在助力早日攻克SCI修复难题,希望能为SCI截瘫治疗带来新的突破。

    Abstract:

    Spinal cord injury (SCI) is a severely disabling central nervous system injury, posing a significant global challenge in clinical medicine. The spinal cord exhibits limited regenerative capabilities and diminished neuroplasticity. The formation of cystic cavities and glial scars subsequent to SCI obstruct nerve conduction, rendering the repair of SCI a formidable undertaking. Currently, effective treatments for SCI remain elusive. "Spinal cord fusion" is an emerging technique designed to repair SCI. This innovative approach primarily leverages fusion agents, a sharp knife and electrical stimulation to expedite nerve fusion and repair, facilitate the regeneration of nerve axons, and reconstruct the complete nerve conduction circuit. The ultimate goal is to restore the lost functions resulting from SCI. By discussing this important research progress and the involved neurological mechanisms, this paper reviews SCI-related studies over the years and introduced the new concept of “Spinal Cord Fusion”. Our aim is to help solve the problem of SCI repair as soon as possible, as well as hoping to bring new breakthrough for the treatment of paraplegia after SCI.

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  • 收稿日期:2023-09-15
  • 最后修改日期:2024-01-05
  • 录用日期:2024-01-11
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